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Testosterone Replacement Therapy for Male Hypogonadism

Testosterone Deficiency Guideline American Urological Association

Testosterone replacement therapy (TRT) is an option for men who have low testosterone levels due to male hypogonadism. TRT involves taking manufactured forms of testosterone to regulate your levels of this hormone. Our men’s health clinic staff at the Low T Center nearest you can quickly and easily determine what type of medical care is needed. We offer total testosterone therapy  solutions for many common conditions that may impact your overall wellness.

Since testosterone replacement therapy is a lifelong treatment, looking into subsidized health insurance can be a smart choice for some people. Typically, Medicare and Medicaid cover TRT as long as the patient meets their state’s criteria for coverage. Popularly linked with male virility, the truth on testosterone is a little more complex. From libido to muscle strength, this key male hormone plays an important role in our sexual health. Multiple studies mention testicular atrophy as a possible side effect of TRT.

You can stop, but the symptoms of low testosterone will probably return. One study followed 151 men for 6 months after they stopped testosterone replacement therapy. The researchers found that for 92 patients (61%), the effects of TRT did not continue, but they did for the other 59 patients (39%). The researchers noted that the people is the second group had been on TRT longer than the people in the first group (10.7 months vs. 5) and they also exercised regularly. A normal range of testosterone for men is anywhere from 300 to 1,000 nanograms per deciliter (ng/dL). But not everyone has symptoms at the same testosterone levels.

Testosterone pellets have a long duration of action; however, they require an in-office procedure. Given the plethora of treatment options and direct-to-consumer pharmaceutical advertising, it is crucial for pharmacists to understand differences between these therapies and educate patients on their profiles and administration techniques. Beyond statistical significance, clinical relevance is another key factor. In analyzing the literature, it is imperative to determine whether or not statistically significant results are clinically meaningful.

500 – 3000 units injected subcutaneously (underneath the skin) every other day. This medication works by increasing the body’s production of testosterone. It is used in various regimens to preserve testicular volume, preserve fertility, and re-stimulate the testicles after periods of testosterone administration. Metered-dose pump/applicator which dispenses 30 mg of testosterone in 1.5 cc solution per pump. The usual starting dose is 1 pump (about the size of 2 quarters) applied to each underarm daily. Liothyronine, a synthetic version of the T3 thyroid hormone also known at Cytomel, treats hypothyroidism symptoms including irregular metabolism and body temperature.

For patients who have an elevated PSA at baseline, a second PSA test is recommended to rule out a spurious elevation. Many men have lowered testosterone levels as they age, and these low testosterone side effects in women levels can start to cause a variety of symptoms. Male hormone replacement therapy, or TRT therapy, is a safe and effective treatment option if you have symptoms or difficulty with low testosterone levels.

Please consult a medical professional before adopting any of the suggestions on this page. You must never disregard professional medical advice or delay seeking medical treatment based upon any content of this newsletter. PROMPTLY CONSULT YOUR PHYSICIAN OR CALL 911 IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY. Multiple topical testosterone products are available in both branded and generic form. All topical products carry the risk of accidental exposure, which could potentially cause virilization in women and children. Patients should avoid washing the product off via showering, swimming, or bathing for the interval specified for the product.

Because of circadian variations in testosterone levels, serum testosterone measurement should occur in the morning, or within two hours of awakening in shift workers (Figure 19 ). Although there is no universal laboratory definition of hypogonadism, in most laboratory reference ranges, the lower limit of normal is between 250 and 350 ng per dL (8.7 to 12.2 nmol per L). Older observational studies suggested that long term testosterone use could increase their risk of cardiovascular disease. Also testosterone is known to stimulate growth of prostate cancer in men diagnosed with the condition. Recent clinical trials, which provide more accurate information compared to observational studies, have provided some comfort around both the heart and prostate cancer risks.

In this type, your pituitary gland produces more luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (known as gonadotropins) in response to low testosterone levels. The high levels of these hormones would normally tell your testicles to produce more testosterone and sperm. However, if you have damaged (most commonly related to prior chemotherapy) or missing testicles, they can’t respond to the increased levels of gonadotropins. As a result, your testicles make too little or no testosterone and sperm. As hormone levels fluctuate depending on activity levels, diet, and the time of day, doctors usually take two different blood samples before noon. They may sometimes also ask for imaging studies and additional tests, such as tests for luteinizing hormone and follicle stimulation hormone, to determine the cause of the low testosterone levels.

This measures free testosterone plus testosterone attached to a blood protein called albumin. This is not a common test, but it can be given to check for certain medical conditions. It measures both testosterone attached to proteins in your blood and testosterone not attached to proteins (called free testosterone). Most testosterone is attached to proteins; the proteins control the amount of active testosterone in your body and prevent your tissues from using the hormone right away. Especially in older men, you’ll want to have your level taken in the morning because a decline is more noticeable if blood is drawn at that time.